Technology

Cardioxyl has developed a nitroxyl (HNO) chemistry platform technology that serves as the foundation for the company's drug discovery efforts. Although nitroxyl chemistry was discovered more than a century ago by the Italian chemist Angelo Angeli, the biological effects of nitroxyl were un-appreciated at that time, and nitroxyl chemistry fell into obscurity for most of the 20th century. The work of Cardioxyl's scientific founders at Johns Hopkins University and their colleagues elucidated the cardiovascular effects of nitroxyl in 2003, and revived interest in this unique chemical space. Cardioxyl has since developed a formidable intellectual property portfolio and industry leading nitroxyl chemistry, pharmacology, manufacturing and formulation expertise.